24th EUROPEAN SYMPOSIUM ON ULTRASOUND CONTRAST IMAGING

17-18 JANUARY 2019, Rotterdam, The Netherlands

 

WEDNESDAY, 16 January 2019

18.00 – 20.00                Registration -  Welcome Drinks [1st floor, Hilton hotel Rotterdam]

 

THURSDAY, 17 January 2019

Oral program

08.00 – 09.00                Registration

09.00 – 09.10                Introduction and opening.......................................................................................................... Peter Burns

 

09.10 – 10.20                (PRE)CLINICAL THERAPY........................................ Chairpersons: Steve Feinstein and Ayache Bouakaz

Kullervo Hynynen             Review of the clinical experience with  enhancing blood-brain barrier permeability using focused ultrasound

                                         and microbubbles.......................................................................................................................................................

John Eisenbrey                 Augmenting radiotherapy with ultrasound-sensitive microbubbles.............................................................................

Paul Sheeran                   Peripheral flow augmentation mediated by microbubble cavitation from a programmable clinical matrix array transducer

Richard Benninger           Detecting pancreatic islet immune infiltration in pre-symptomatic type1 diabetes using sub-micron scale ultrasound

                                         contrast agents..........................................................................................................................................................

10.20 – 10.55                Postersessions C and D

10.55 – 11.10                Coffee

11.10 – 12.40                THERAPY: Towards clinical use.............................. Chairpersons: Beat Kaufmann and Folkert ten Cate

Pintong Huang                 A Novel Therapeutic Strategy using Ultrasound Mediated Microbubbles Destruction to Treat Colon Cancer in

                                         A Mouse Model..........................................................................................................................................................

Constantin Coussios         Passively Mapped Cavitation-Enhanced Oncological Drug Delivery using Sub-Micron Gas-Stabilizing Solid Particles

Jean-Michel Escoffre        Nab-paclitaxel delivery with microbubble-assisted ultrasound in human pancreatic cancer mouse model.................

Twan Lammers                Visualizing and Quantifying Sonoporation-induced Nanocarrier Translocation across the Blood-Brain Barrier.........

John Pacella                     Ultrasound-targeted microbubble cavitation with sodium nitrite synergistically enhances nitric oxide production

                                         and microvascular perfusion

 

12.40 – 13.40                LUNCH

13.40 – 14.10                DUTCH HEART FOUNDATION LECTURE.............................. Chairperson: Annemien van den Bosch

Wilson Mathias                 Clinical Outcome of Patients Treated With Diagnostic Ultrasound Guided High Mechanical Index Impulses

                                         To Restore Microvascular Flow in ST segment Elevation Acute Myocardial Infarction..............................................

14.10 – 15.40                THERAPY: The Basics ................................................... Chairpersons: Olivier Couture and Klazina Kooiman

Eleanor Stride                  A Multi-Bubble Sonoluminescence in Sonodynamic Therapy.....................................................................................

Christy Holland                 Lipid-shelled microbubbles for ultrasound-triggered release of Xenon for neuroprotection.......................................

Brandon Helfield               Transendothelial perforations and the sphere of influence of single site sonoporation..............................................

Inιs Beekers                    Cellular calcium during microbubble-mediated drug delivery revealed with combined confocal microscopy and

                                         Brandaris 128 imaging...............................................................................................................................................

Silke Roovers                   Liposome-loaded microbubbles and ultrasound enhance drug delivery in a 3D tumor spheroid

                                        

15.40 – 16.10                Intermission

 

16.10 – 17.40                HIGH FRAME RATE IMAGING............................................. Chairpersons: Dan Adam and Mike Averkiou

Olivier Couture                 Brain ultrasonography, with and without contrast agents...........................................................................................

Jason Voorneveld             High-volume-rate 4D echoPIV, in vitro results in a dynamic left ventricular phantom.................................................

Baptiste Heiles                  Volumetric ultrafast Ultrasound Localisation Microscopy in vivo.................................................................................

Mengxing Tang                Towards Real-Time Super-Resolution Imaging: Fast Acoustic Wave Sparsely Activated Localization Microscopy

                                         (fast-AWSALM) using Octafluoropropane Nanodroplet.............................................................................................

Annemien van den Bosch Left ventricular flow patterns: A new aspect elucidated by high-frame rate echocardiography..................................

 

18.30 – 22.30                EVENING PROGRAM (Incl. Dinner buffet)

                                         24th EUROPEAN SYMPOSIUM ON ULTRASOUND CONTRAST IMAGING

17-18 JANUARY 2019, Rotterdam, The Netherlands

FRIDAY, 18 January 2019

07.30 – 08.00 Registration

 

07.30 – 09.00           MODERATED POSTER SESSIONS A and B

 

Oral program

09.00 – 10.10                BUBBLE TECHNOLOGY........................................................... Chairpersons:  Michel Versluis and Rik Vos

Mark Borden                    A study of radiation force effects in plane-wave transmission mode..........................................................................

Steven Wrenn                  Influence of Electric Field on Acoustic Spectra of Nested Contrast Agents................................................................

Tim Segers                       Tunable shell stiffness of phospholipid coated monodisperse microbubbles for non-invasive blood pressure measurement

David Maresca                 Nonlinear X-Wave Ultrasound Imaging of Acoustic Biomolecules..............................................................................

 

10.10 – 10.45                Postersessions E and F

10.45 – 11.00                Coffee

 

11.00 – 12.30            CLINICAL CONTRAST IMAGING............................... Chairpersons: Pintong Huang and Arend Schinkel

Steven Feinstein               Vascular imaging: Biomarker of systemic atherosclerosis/inflammation.....................................................................

Misun Hwang                   Quantitative CEUS Parameters for Detection of Neonatal Hypoxic Ischemic Injury...................................................

Norbert Lorenz                 Intravenous CEUS in a pediatric setting - common and rare applications..................................................................

Rogier Wildeboer             Prostate cancer localization based on multiparametric quantification of three-dimensional transrectal

                                         contrast-enhanced ultrasound...................................................................................................................................

Reinhard Kubale              Quantification of Endoleaks in EVAR..........................................................................................................................

                                        

12.30 – 13.30                Lunch

 

13.30 – 15.15                COMPETITION: IMAGE GUIDED THERAPY.............. Chairpersons: Eleanor Stride and Nico de Jong

Ryan Jones                      Ultrafast Three-Dimensional Microbubble Imaging Predicts Tissue Damage Following Nonthermal Brain Ablation..

Sophie Morse                   Single-cycle ultrasound drug delivery and passive acoustic mapping in the brain in vivo............................................

Christophoros Mannaris   Predictive Real-Time Monitoring of Cavitation-Enhanced Immunotherapies by Passive Acoustic Mapping...............

Aditi Bellary                       Perfusion-Guided Monitoring of Tumor Response to Sonoporation and Prediction of Liposomal Doxorubicin Uptake

                                         Using Microbubble Contrast Agents...........................................................................................................................

Dingjie Suo                       Image-guided bubble-enhanced thermal ablation......................................................................................................

Alexander Klibanov           Image-guided therapy with ultrasound and microbubbles:   a tool to monitor in vivo events in real time....................

 

15.15 – 15.45                COEUR LECTURE................................................................................................... Chairperson: Peter Burns

Fabian Kiessling               The magnificent bubble: More than just air................................................................................................................

 

16.00 – 16.10                DISCUSSION AND CONCLUSIONS................................................................................................................

16.00 – 16.10                Closing remarks..................................................................................................................... Nico de Jong

16.10                               Farewell drinks

                                         Announcement of the winners of the Competition and poster prizes

 

 

 

Organised by:             Nico de Jong, Folkert ten Cate, Rik Vos, Klazina Kooiman, Annemien van den Bosch, Arend Schinkel

Scientific board:         Mike Averkiou, Mark Borden, Paolo Colonna, Olivier Couture, Beat Kaufmann, Eleanor Stride.

 


24th EUROPEAN SYMPOSIUM ON ULTRASOUND CONTRAST IMAGING

17-18 JANUARY 2019, Rotterdam, The Netherlands

 

Poster sessions Thursday

 

Thursday 10.25-11.10.................................................................. POSTER SESSION C: NEW DIRECTIONS TECHNOLOGY I   Election by the audience

C1)   Hongjian Chen        Sequence design for ultrasound imaging of polyvinyl alcohol microbubbles...............................................................

C2)   Isabel Newsome     Assessment of the Superharmonic Response of Microbubble Contrast Agents for Acoustic Angiography

                                         .................................................................................................................. As A Function of Microbubble Parameter  

C3)   Hugo Robert           Longitudinal Follow-up Analyses for Quantification of Contrast-Enhanced Ultrasound Imaging................................

C4)   Gonzalo Collado      Measuring the effect of Radiotherapeutic Radiation on Commercially Available Microbubbles..................................

C5)   Ryan Hammond      Segmentation of stationary microbubbles: the foundation for targeted molecular imaging........................................

C6)   John Hossack          Catheter-based, instrumented, flow focusing microfluidics device for production, counting and sizing of monodisperse

                                         ............................................................................................................ microbubbles optimized for sonothrombolysis  

C7)   Jason Voorneveld   High frame rate echoPIV reveals the transient flow patterns in heart failure patients................................................

C8)   Laura Peralta Pereira / .............................................. Microbubble Contrast Agents for Coherent Multi-Transducer Ultrasound Imaging  

         Kirsten Christensen

C9)   Stefan Engelhard    Contrast-Enhanced Ultrasound for velocimetry in the diseased aorto-iliac tract........................................................

 

 

Thursday 10.25-11.10............................................................................... POSTER SESSION D: NEW DIRECTIONS CLINICAL   Election by the audience

D1)   Christophe Mannaerts ........ Detection of significant prostate cancer: Contrast-enhanced ultrasound and multiparametric MRI-targeted

                                         ............................................................................................... biopsy in comparison with standard systematic biopsy  

D2)   Noboru Sasaki        Ultrasound-mediated intravesical chemotherapy: ex vivo evaluation..........................................................................

D3)   Roel Deckers          Ultrasound-sensitive liposomes for macromolecular drug delivery.............................................................................

D4)   Mindaugas Tamošiūnas ................... Cytotoxicity evaluation of sonodynamic therapy combined with microbubble contrast agent in vitro  

D5)   Josanne de Maar    ... Bleomycin plus ultrasound and microbubbles to treat feline oral squamous cell carcinoma, as a model for human

                                         ................................................................................. head and neck cancer, study design of the BUBBLEFISH Trial  

D6)   Matthew Copping    Drug delivery across the blood-brain barrier using short 300-kHz pulses of ultrasound and microbubbles...............

D7)   Rahul Misra             3D tumor spheroid model for in-vivo therapeutic predictions of Sonochemotherapy.................................................

D8)   Xucai Chen             STAT3 Decoy Oligonucleotide-carrying Microbubbles with Pulsed Ultrasound for Enhanced Therapeutic Effect

                                         ......................................................................................................................................... in Head and Neck Tumors  

D9)   Joop Kouijzer          Targeted microbubbles as a novel therapy for Staphylococcus aureus biofilms on cardiac devices...........................

D10) Charis Rousou        Therapeutic applications of ultrasound for retinal drug delivery using in vitro and ex vivo models

 

 

 


 



24th EUROPEAN SYMPOSIUM ON ULTRASOUND CONTRAST IMAGING

17-18 JANUARY 2019, Rotterdam, The Netherlands

FRIDAY, 18 January 2019

07.30 – 08.00 Registration

Poster sessions Friday

07.30 – 09.00                MODERATED POSTER SESSION A: BIOLOGY/CLINICAL........................ Moderator: Klazina Kooiman

A1)    Anne Rix                 Contrast enhanced ultrasound treatment enhances tumor perfusion in breast cancer patients – first results...........

A2)    Yue Song                Ultrasonic Induction of Apoptosis of Pancreatic Cancer through Activation of the Mechanosensitive Channel Piezo.

A3)    Ragnhild Haugse    Sonoporation efficacy and intracellular mechanisms: Cancer cells vs. healthy cells...................................................

A4)    Gareth LuTheryn    ULTRASOUND RESPONSIVE BIOACTIVE MICROBUBBLES FOR THE ERADICATION OF BIOFILMS..............

A5)    Tiffany Chan           Ultrasound-mediated delivery of DNA-coated gold nanoparticles across the blood-brain barrier..............................

A6)    Oliver Vince             The role of microbubble composition in sonoporation................................................................................................

A7)    Filip Istvanic             Clinical Translation of Sonoreperfusion Therapy for Treatment of Microvascular Obstruction...................................

A8)    Liza Villanueva        Ultrasound-mediated antitumor efficacy of liposomal doxorubicin conjugated polymer microbubbles with

                                         ................................................................................ reduced cardiotoxicity in a mouse model of soft tissue sarcoma  

      07.30 – 09.00          MODERATED POSTER SESSION B: TECHNOLOGY................................................ Moderator: Rik Vos

B1)    Kenneth Bader        Classification of histotripsy liquefaction in vitro with passive cavitation imaging...........................................................

B2)    Pauline Muleki-Seya............................................................................................................................ Ultrafast radial modulation imaging  

B3)    Emmanuel Gaud     The Bubble Counter: a unique device for the precise control of microfluidically formed monodisperse microbubbles  

B4)    Peiran Chen            Blood flow patterns analysis in the left ventricle by dynamic contrast-enhanced ultrasound at low frame rates.........

B5)    Jemma Brown         High Dynamic Range Non-linear Ultrasound Imaging...............................................................................................

B6)    Jorinde Kortenbout Repeatability of contrast enhanced ultrasound to measure cerebral blood flow using the middle cerebral artery

                                         ............................................................................................................................................................ as a reference  

B7)    Luzhen Nie              Motion Compensation for High Frame-rate Contrast-enhanced Echocardiography using Diverging Waves.............

B8)    Kirsten Christensen /............................................................ 3D Super-Resolution Ultrasound Imaging In Vitro using a 2D Sparse Array  

         Mengxing Tang

 

Friday 10.15-11.00     POSTER SESSION E: NEW DIRECTIONS UCA.................................................... Election by the audience

E1)    Ryo Suzuki              Development of a long-circulating ultrasound contrast agent.....................................................................................   

E2)    Sophie Heymans     Investigation of PCDA-PFB nanodroplets for multimodal imaging and in vivo dosimetry of radiation therapy............   

E3)    Amanda Pessoa      Microfluidic production of fibrin-targeted polymerized shell microbubbles..................................................................

E4)    Yosra Toumia         Graphene Hybrid Contrast Agents for Ultrasound and Multiplexed Photoacoustic Imaging.......................................

E5)    Andrea Ancona       Focused ultrasound induced inertial cavitation by amino-propyl functionalized ZnO nanoparticles............................   

E6)    Fabio Domenici       Development of a polymeric contrast platforms.........................................................................................................

E7)    Alexandra Kosareva..................................................................................................................................................................................    Targeting of vascular cell adhesion molecule 1 with an ultrasound contrast agent bearing Designed Ankyrin Repeat

                                         ...................................................................................................................................... Proteins as targeting ligands  

E8)    Shashank Sirsi        Formulation and Stability of Chemically-Crosslinked Microbubble Clusters: Novel Applications in Imaging and Therapy

E9)    Simone Langeveld  Lipid coating structure and acoustic response of ultrasound contrast agents containing cholesterol..........................

E10)  Sara Ferri               Acoustically-stimulated nanodroplets for bone fracture repair....................................................................................

 

Friday 10.15-11.00     POSTER SESSION F: NEW DIRECTIONS TECHNOLOGY II............................. Election by the audience

F1)    Gihun Son               Level-set based numerical simulation of acoustic droplet vaporization.......................................................................

F2)    Eliott Teston            Ultrasound precise vaporization threshold microdroplets...........................................................................................

F3)    Simona Turco         Pharmacokinetic analysis of targeted nanonubbles for quantitative assessment of PSMA expression in prostate cancer

F4)    Catherine Paverd    Multi-Source Passive Acoustic Source Localisation for Diagnostic and Therapeutic Applications...............................

F5)    Cameron Smith       Spatiotemporal assessment of the cellular safety of cavitation-based therapies by passive acoustic mapping...........

F6)    Roger Domingo-Roca...................................... Microbubble – microvessel interactions and their influence on UmTDD: Simulation study  

F7)    Sara Keller              Real-time Cavitation Therapy Monitoring with a Clinical Scanner..............................................................................

F8)    James Bezer           Single-bubble-induced elastic deformation of capillary-mimicking hydrogel channels.................................................

F9)    Michael Calvisi         A novel model for an encapsulated microbubble based on transient network theory.................................................